Since I discovered rss feeds, I have tried many feed readers, but all the applications didn’t work for me, I needed a web-based reader. Why? I need to be able to access it from multiple computers, making it difficult to sync read/unread items. A web app solves this by being accessible from anywhere.
I ended up settling on Bloglines, and used it for about a year. I have recently switched to using Gregarius. Its a nifty PHP feed reader that’s skinnable and has lots of plugins to customise it. The user-interface is also much better than Bloglines, and since its skinnable, if you don’t like how it looks, make your own skin!
Its obviously not a hosted service, so you need some web space, but I much prefer it. Its nice to be in control. 🙂